by Leslie Print with Belt amp; with Kasper Vintage Jacket Joan Dress Squares fCEqR7w

Preeclampsia was once called “the disease of theories,” but research efforts this past decade have produced exciting breakthroughs that may bring us closer to causality, improve diagnosis and even prediction, and lead to prevention and/or specific treatments. Some speculation remains over different theories including: changes in biology of the placenta, the systemic inflammatory response, a variety of hormones and other proteins that are in the mother’s circulation, changes in immune factors, improper cardiovascular adaptations to the pregnant state, underlying maternal risks for cardiovascular disease, associations with insulin resistance and diabetes, and deficiencies in essential nutrients, minerals, and vitamins. 

The most plausible theories focus on the placenta and describe the disorder in two stages. In the first, the initiating cause results in the placenta producing factors (e.g., specific proteins, placental “debris”) that enter the maternal circulation and are believed responsible for producing the next stage. This is the second stage, which results in the overt maternal “disease” (high blood pressure, kidney, liver and coagulation abnormalities).  The overt disease depends not only on the action of the circulating factors from the placenta, but also the health of the mother, including diseases that may affect the vasculature (such as preexisting cardiovascular, renal, metabolic, and genetic factors; and obesity). A quick chart of potential causes can be found in our FAQsFashion 42 for size Napoleon Funky men Jacket ExwvEaqf.

with by Joan amp; Jacket Dress with Belt Leslie Squares Kasper Vintage Print
A promising area of recent research involves the role of proteins produced by the placenta that inhibit angiogenesis (the production of new blood vessels).  Two of these “antiangiogenic factors” (soluble Fms-like tyrosine kinase-1, and soluble endoglin) have been shown to produce a preeclampsia like disease in rodents. Their concentrations rise in the mother’s circulation weeks to months before the disease manifests.  Placentas of women destined to develop preeclampsia overproduce these proteins that then enter the mother’s circulation.  Neutralizing their actions is now being investigated in animal models, and in some studies has reversed the disease in rodents. .  Excitement regarding these interventions is tempered by a limited understanding of the functional role of antiangiogenic substances in normal pregnancy.

If the ability of these antiangiogenic proteins to cause preeclampsia is confirmed by research in humans, why the placenta overproduces them remains unknown. Hence, many of the other areas of investigation mentioned above may be important.  Preeclampsia may have multiple causes, and other leads are being investigated, including prostaglandins, digoxin-like molecules, immunological mechanisms, autoantibodies that trigger receptors that lead to vessel constriction (agonistic autoantibodies to the angiotensin 1 receptor), oxidative stress, mitochondrial pathology, the impact of hypertension and prehypertension on endovascular health, and genes sensitive to low oxygen environments. 

Basic research into causes of preeclampsia, lacking for decades, is being revitalized, albeit more slowly than needed. While we are moving closer to historically elusive answers, the true cause of preeclampsia remains unknown. Successful ongoing  research needs far more support and funding.

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This is an Amazing vintage 60s Joan Leslie by Kasper Dress with Squares Print with Jacket & Belt. The design really stands out. Dress has a back metal zipper. For your Elegant occasions or to just be the life of the party.







Material - Cotton Like Material







Size - Please check measurements to ensure a proper fit!



Approximate Measurements (Taken flat - already doubled):







Dress



Bust: 40 inches



Waist: 32 inches



Hips: 46 inches







Total length of dress: 39 inches







Jacket



About 40 inches - Buttoned







Label: Joan Leslie by Kasper







Condition: Good. The only thing noticeable (when holding it close to face) is a stain on the left Bust. Please message us for any additional pictures if you think this may be an issue for you :)







Please note this dress is at least 48 years old! There will naturally be some minor flaws not noted above that do not take away from the beauty of the dress.







Item is sold as is an cannot be returned. Please message us with any questions before purchasing the dress. We are more than happy to provide additional photos of the dress as well.







Please note that this item is in our Brick and Mortar Store for sale and so that potential buyers (including online) can try it on to ensure a fitting. We will do our best to take it off the rack or Etsy (which ever sells first) when it sells. If by the off chance that this item sells first in our physical store, we will refund you completely, and provide you with a coupon code for your next purchase.







Please contact us for International shipping.
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